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Dorry L. Segev is the head of the Center for Surgical and Transplant Applied Research at NYU Langone Health. Previously he served as the Marjory K. and Thomas Pozefsky Professor of Surgery at Johns Hopkins School of Medicine, professor of epidemiology at Johns Hopkins Bloomberg School of Public Health, and associate vice chair of the Department of Surgery at Johns Hopkins Hospital. He has made significant contributions to the field of transplantation, including developing a mathematical model to facilitate a nationwide kidney paired donation program, both in the US and Canada. He is also known for his role in getting the HIV Organ Policy Equity Act (or HOPE Act) signed into law.
Both Segev and his wife, Sommer Gentry, have been featured in The Baltimore Sun, Science, Time, and The New York Times.Hamilton, A. (2005). Calculating Change: The Kidney Connection: Math Makes a Match. http://content.time.com/time/magazine/article/0,9171,1101302,00.html. Retrieved April 7, 2016.Victor, Daniel. "Johns Hopkins to Perform First H.I.V.-Positive Organ Transplants in U.S." The New York Times, 2016. Web. Retrieved April 14, 2016.
Segev is the director of the Epidemiology Research Group in Organ Transplantation at Johns Hopkins University.
The first kidney-paired donation was performed in South Korea in 1991, followed by one in Europe in 1999.Ellison, Blake (2014-05-16). "A Systematic Review of Kidney Paired Donation: Applying Lessons From Historic and Contemporary Case Studies to Improve the US Model". Wharton Research Scholars Journal. 107. Retrieved 2016-08-23. Sommer Gentry and Dorry Segev found that the existing matching programs were not sufficient to accommodate the scale of the transplant waitlist in the United States. Previous matching programs limited kidney-transplant patients and their families to connect with other incompatible pairs on their own. Together, Segev and Gentry devised a nationwide system to match donor-patient pairs. Based on an algorithm created by the Canadian mathematician Jack Edmonds in 1965, the system improves paired donation by ensuring the maximum number of matches while still factoring in age, location and willingness to travel.Hamilton, Anita. "Calculating Change: The Kidney Connection: Math Makes a Match". Time, September 4, 2005, content.time.com/time/subscriber/article/0,33009,1101302,00.html
Under the direction of Segev and Robert Montgomery, Johns Hopkins completed the first five-way donor kidney swap among 10 individuals.
The longest kidney-pair chain to date included 70 participants and was completed in 2014.Pitts; Louszko; Cappetta; Effron; Valiente (15 Apr 2015). "Changing Lives Through Donating Kidneys to Strangers". ABC News Nightline.
In May 2010, Brian Boyarsky sought out Segev's advice after doing previous research comparing transplant programs in different countries. During his research, Boyarsky met Elmi Muller, who had been successfully transplanting organs between HIV+ donors and recipients in South Africa.Boyarsky, Brian and Dorry L. Segev. "From Bench to Bill: How a Transplant Nuance Became 1 of Only 57 Laws Passed in 2013" Annals of Surgery Volume 263(3). (2016): 430-433. Print. With that in mind, Segev and Boyarsky looked at both the Nationwide Inpatient Sample to study in-hospital deaths of HIV+ patients and the HIV Research Network, which provided granular disease-specific data, to calculate the impact of using organs from HIV+ donors on the organ transplant waitlist. Both data sources allowed Segev and Boyarsky to estimate a possible 500 to 600 HIV+ donors in the United States, whose organs were currently being discarded.Boyarsky BJ, Hall EC, Singer AL, et al. Estimating the potential pool of HIV-infected deceased organ donors in the United States. Am J Transplant 2011; 11:1209–1217.
After appearing on the front page of The New York Times and Boyarsky's article appearing in the American Journal of Transplantation, Segev and his mentee visited every major national transplant and AIDS advocacy group in the US.Belluck, Pam. "A New Push to Let H.I.V. Patients Accept Organs That Are Infected". The New York Times, April 10, 2011, www.nytimes.com/2011/04/11/us/11hiv.html. Within weeks, they had every group officially supporting their campaign to legalize using organs from HIV+ donors for HIV+ recipients. In August 2011, Segev and Boyarsky sought out bipartisan support to change the existing law. California Senator Barbara Boxer (D) and Oklahoma Senator Tom Coburn (R) became the main sponsors of the bill first drafted by Segev and Boyarsky. They were later joined by congressional representatives Lois Capps (D) and Andy Harris (R) to support the bill in the House of Representatives.
The HIV Organ Policy Equity Act (or HOPE Act) was introduced in the Senate on February 14, 2013.
President Barack Obama signed the HOPE Act into law on November 21, 2013.Colfax, Grant, MD. "HIV Organ Policy Equity (HOPE) Act Is Now Law". The White House, November 21, 2013. Web. April 14, 2016.
With the HOPE Act, HIV positive patients on the current kidney and liver waiting lists can elect to also be open to any organs whose donors were diagnosed with HIV. This would not remove the patients from accepting non-HIV positive organs. However, it does have the potential to significantly shorten a patient's wait time on the kidney and liver deceased donor wait list."HIV-to-HIV Transplant Media Briefing". YouTube. Johns Hopkins Medicine, March 31, 2016. Web. April 14, 2016.
The first HIV-to-HIV transplants in the United States were performed on March 30, 2016, at Johns Hopkins University.Christensen, Jen. "First Liver Transplant between HIV-positive Patients". CNN. March 31, 2016. Web. April 14, 2016.
Segev is an international teacher in swing dance and Lindy Hop with Gentry.Redfern, Suz. "Dorry Segev, Extreme Renaissance Man". Dorry Segev, Extreme Renaissance Man. 12 Apr. 2015. Web. April 14, 2016. In 2005, Segev and Gentry started Charm City Swing, a non-profit organization in Baltimore, Maryland, that is dedicated to introducing the art of swing dance to non-dancers.Lindy Hop and Swing Dance in Baltimore and Worldwide. (n.d.). http://www.dorryandsommer.com/. Retrieved April 7, 2016. Charm City Swing found a permanent home at the Mobtown Ballroom in 2012.
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